Redefining Mental Health with Your Wellness at the Core

Upton Wellness

  • Psychiatric Medication Management

    We provide expert psychiatric medication management with a thoughtful, individualized approach. Treatment plans are carefully tailored and continuously refined to optimize mental health, improve daily functioning, and support long-term stability.

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  • Psychotherapy

    Internal Family Systems (IFS) is a psychotherapy model that perceives the mind as composed of various parts with unique thoughts, emotions, and actions. It seeks to foster harmony among these parts by tapping into inner resources and uncovering the roots of emotional distress. Through this process, individuals can develop greater self-awareness, self-compassion, and a more integrated sense of self.

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  • Ketamine Assisted Psychotherapy

    Ketamine, renowned for its swift transformational effects, rapidly alleviates anxiety, depression, and related conditions. Ketamine disrupts negative feelings and preoccupations - helping the brain create new, healthier patterns.

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  • Hormone Replacement Therapy

    Have you ever wondered if hormones are playing a role in your health, wellness, and happiness? Upton Wellness and The Armory recognize this relationship and strive to improve the wellbeing of every patient as a whole person. We collaborate with The Armory to provide male and female hormone replacement therapy for those that qualify. 

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Meet Dr. Upton DNP, PMHNP

Dr. Cole Upton, DNP, PMHNP-BC, is the founder of Upton Wellness, a boutique psychiatric practice rooted in holistic, whole-person care. Dr. Cole Upton is a board-certified Psychiatric Mental Health Nurse Practitioner. His approach is shaped by both rigorous clinical training and a deep belief that true healing requires more than symptom management — it requires understanding the person behind the diagnosis.

Raised in the close-knit community of West Liberty, Ohio, Dr. Upton developed an early appreciation for simplicity, authenticity, and meaningful connection. Those values continue to inform the way he practices today: thoughtfully, relationally, and without rush.

After earning his Doctor of Nursing Practice degree from the University of Cincinnati, he established his career in Columbus, drawn to its balance of innovation and community. Over the years, he has worked across the full continuum of psychiatric care, including psychiatric emergency services, adolescent and adult inpatient psychiatry, geriatric inpatient psychiatry, outpatient psychiatry, IV and sublingual ketamine-assisted psychotherapy, and electroconvulsive therapy (ECT).

As a travel nurse in Seattle, Washington, Dr. Upton gained experience serving diverse populations within large healthcare systems. These roles provided invaluable clinical depth — and also clarified something important: many patients were receiving treatment, but not always receiving individualized, integrated care.

That realization became the foundation for Upton Wellness.

Today, Dr. Upton offers a person-centered model that blends evidence-based psychiatry with lifestyle medicine, therapy collaboration, and intentional, unhurried appointments. His work is grounded in precision, guided by compassion, and designed for lasting change.

Dr. Upton is honored to walk alongside his patients as they build lives marked not only by stability, but by clarity, resilience, and genuine well-being.

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Testimonials

  • Dr. Cole Upton is hands down the best doctor I’ve been to! His approach and the way he gets to know you to find the root cause as to what is going on is refreshing to experience in this current state of medicine. Do yourself a favor and schedule a consult with him.

    Tom J.

  • Dr. Upton is amazing! I was thrilled after moving back to Ohio from Florida to find a psychiatrist that offered KAP, in addition to regular counseling/medication management. His open mindedness, and unique holistic approach with background in psychiatry, has been incredible for my journey of healing!

    Amy S.

  • Dr Upton is a fantastic MH provider! He takes the time to listen and I never feel rushed when I see him. He is also very responsive when I need a med refill. Definitely recommend his services!!

    Kathy P

  • Dr. Cole Upton is amazing. He has helped my ADHD tremendously. He actually cares about and listens to your needs.

    -Robbie

  • Cole is an excellent clinician. He listens to the individual and provides custom made treatment plans. Ver highly recommended 👍🏻👍🏻

    Dave H.

  • Dr. Upton was professional, understanding, kind, and offered confirming support and an excellent overview of my medications with suggestions to improve them. He is the best!

    Brian K.

  • Dr Upton exceeded my expectations. It can be difficult finding a provider for my teenage daughter that makes her feel comfortable and also makes her feel that she is being heard. Dr Upton took the time to listen to her needs and included her in on his treatment plan. I will recommend him to anyone looking for a provider.

    Gracie W.

  • The most positive experience I have had with a provider. Very patient and took the time to listen. Would highly recommend.

    Rina S.

  • Doctor Upton was fantastic. He listened very closely, took my feelings, and my opinions on my health and quality of life very seriously. He asked me numerous questions about different medications. Some I had used before and some I had not. What was refreshing was, Dr. Upton and I came up with a medication together that looked to be the best fit for my needs. He was 100% transparent and offered me to call or message anytime, if I had questions or concerns. I would recommend Dr. Upton to anyone looking for a great doctor, that has their patients best interest at heart.

    Matthew M.

  • I love being able to be honest about what’s going on and being able to give my input on my treatment plan. Dr. Upton looks for more options than just prescribing medication, he looks at the whole picture. I’ve always been nervous to see different providers because I felt like what I wanted wasn’t considered. Dr. Upton goes above and beyond to make sure your needs are met, but also truly listens to what your goals are. I have already recommended him to all of my friends and family, and would not hesitate to recommend him to anyone.

    -AC

  • My first appointment with Dr. Upton is by far the best encounter I’ve had with ANY hcp since moving back to Ohio. He is friendly and put my very anxious mind at ease with his calm courteous demeanor and excellent clinical insight… I had no issue with pharmacy after appointment and he did as we agreed… I am looking forward to our next appointment- that is a first in my psych history. Lastly, he was precisely on time thus respected my time, a rarity today… I hope to give him a similar review after 1,3,5 years, so please check back

    DB

  • Dr. Upton is very professional and extremely helpful. He took the time to help me find the right medication and dosage to effectively treat my ADHD. He has very quick response times and he’s incredibly knowledgeable. Highly recommend

    Jason W.

  • I can’t tell you how far I have come in such a short period of time. Working closely with Cole and allowing his skill set of finding the right medications, defining key issues to work through and his ability to ask the questions that move you through therapy. I have accomplished more in 2 months than in 20 years of therapy. The Ketamine program under the watch of Cole has proved to be the best investment I ever made!

    Robin S.

  • Dr Cole Upton is insightful, thought-provoking, and extremely easy to work with (scheduling, etc). I have had many breakthroughs in healing trauma since we began our work together a few months ago. I highly recommend him.

    Sarah Lyons